Publications

DAE-SIK LIM‬ - ‪Google Scholar‬ 

1. Jeon, H. Y., Choi, J., Kraaier, L., Kim, Y. H., Eisenbarth, D., Yi, K., ... & Lim, D. S. (2022). Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism. The EMBO Journal, e109365. 

2. Hwang, D., Kim, M., Kim, S., Kwon, M. R., Kang, Y. S., Kim, D., ... & Lim, D. S. (2021). AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. Life Science Alliance, 4(10). 

3. Yuan, T., Annamalai, K., Naik, S., Lupse, B., Geravandi, S., Pal, A., Dobrowolski, A., Ghawali, J., Ruhlandt, M., Gorrepati, K., Azizi, Z., Lim, D. S., Maedler, K., & Ardestani, A. (2021). The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nature communications, 12(1), 4928. 

4. Tang, F., Gao, R., Jeevan-Raj, B., Wyss, C. B., Kalathur, R., Piscuoglio, S., Ng, C., Hindupur, S. K., Nuciforo, S., Dazert, E., Bock, T., Song, S., Buechel, D., Morini, M. F., Hergovich, A., Matthias, P., Lim, D. S., Terracciano, L. M., Heim, M. H., Hall, M. N., … Christofori, G. (2019). LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nature communications, 10(1), 5755.

5. Park, J., Eisenbarth, D., Choi, W., Kim, H., Choi, C. Lee, D. and Lim, D.S. YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice. In Press, Cancer Research (2020)

6. Hong, S. P., Yang, M. J., Cho, H., Park, I., Bae, H., Choe, K., Suh, S. H., Adams, R. H., Alitalo, K., Lim, D., & Koh, G. Y. (2020). Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nature communications, 11(1), 4102. 

7. Park, J., Kim, J. S., Nahm, J. H., Kim, S. K., Lee, D. H., & Lim, D. S. WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice. Molecules and Cells 43.5 (2020): 491-499.

8. Choi, S. Y., Bae, H., Jeong, S. H., Park, I., Cho, H., Hong, S. P., ... & Choi, J. (2020). YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nature Communications, 11(1), 1-15.

9. Koo, J. H., Plouffe, S. W., Meng, Z., Lee, D. H., Yang, D., Lim, D. S., ... & Guan, K. L. (2020). Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes & Development, 34(1-2), 72-86.

10. Tang, F., Gao, R., Jeevan-Raj, B., Wyss, C. B., Kalathur, R., Piscuoglio, S., Ng, C., Hindupur, S. K., Nuciforo, S., Dazert, E., Bock, T., Song, S., Buechel, D., Morini, M. F., Hergovich, A., Matthias, P., Lim, D. S., Terracciano, L. M., Heim, M. H., Hall, M. N., … Christofori, G. (2019). LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nature communications, 10(1), 5755.

11. Tran, T. H. Y., Yang, D. W., Kim, M., Lee, D. H., Gai, M., Di Cunto, F., ... & Lim, D. S. (2019). Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif. Journal of molecular cell biology, 11(11), 1006-1017.

12. Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., ... & Koh, G. Y. (2019). A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis. Nature communications, 10(1), 1-17.

13. Cho, H., Kim, J., Ahn, J. H., Hong, Y. K., Mäkinen, T., Lim, D. S., & Koh, G. Y. (2019). YAP and TAZ negatively regulate Prox1 during developmental and pathologic lymphangiogenesis. Circulation research, 124(2), 225-242.

14. Ikeda, S., Mizushima, W., Sciarretta, S., Abdellatif, M., Zhai, P., Mukai, R., ... & Farrance, I. (2019). Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte dedifferentiation during pressure overload. Circulation research, 124(2), 292-305.

15. Yazdchi, S. B., Witalis, M., Meli, A. P., Leung, J., Li, X., Panneton, V., ... & Lim, D. S. (2019). Hippo pathway kinase Mst1 is required for long-lived humoral immunity. The Journal of Immunology, 202(1), 69-78.

16. Bae, J. S., Jeon, Y., Kim, S. M., Jang, J. Y., Park, M. K., Kim, I. H., ... & Lee, H. (2018). Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling. Cell death & disease, 9(11), 1-13.

17. Hagenbeek, T. J., Webster, J. D., Kljavin, N. M., Chang, M. T., Pham, T., Lee, H. J., ... & Yang, N. (2018). The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors. Science signaling, 11(547).

18. Kim, J., Hong, C. M., Park, S. M., Shin, D. H., Kim, J. Y., Kwon, S. M., ... & Lee, D. (2018). SURF4 has oncogenic potential in NIH3T3 cells. Biochemical and biophysical research communications, 502(1), 43-47.

19. Jeong, S. H., & Lim, D. S. (2018). Insulin receptor substrate 2: a bridge between Hippo and AKT pathways. BMB reports, 51(5), 209.

20. Choi, W, Kim, J, Park, J, Lee, D, Hwang, D... Lim, DS. YAP/TAZ initiates gastric tumorigenesis via upregulation of MYC. Cancer Research (2018) DOI: 10.1158/0008-5472.CAN-17-3487

21. Jeong, S, Kim, H, Kim M, ... Lim, DS. Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. J. Clin. Invest. (2018) 128(3):1010-1025. https://doi.org/10.1172/JCI95802

22. Kim, JS….., Lim DS, and Koh GY.. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest.(2017). doi:10.1172/JCI9382

23.  Jang, W, Kim, T, Koo, JS, Kim, SK, & Lim, DS. Mechanical cue‐induced YAP instructs Skp2‐dependent cell cycle exit and oncogenic signaling.The EMBO Journal (2017). e201696089.

24. Lee, BS, Park, DI, Lee, DH, Lee, JE, Yeo, MK, Park, YH, ... & Kang, D. Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma. Biochemical and Biophysical Research Communications (2017).

25. Yoo, G, Kim, T, Chung, C, Hwang, DS., & Lim DS.. The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3β-mediated TAZ destabilization. Biochemical and Biophysical Research Communications, (2017) 490(3), 650-656

26. Robertson, A, Mohamed, T, M, El Maadawi, Z, Stafford, N, Bui, T, Lim DS., ... & Oceandy, D. Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Research, (2017) 20, 42-49

27. Kim T*, Hwang D*, Lee D, Kim JH, Kim SY, Lim DS. MRTF potentiates TEAD-YAP transcriptional activity causing cancer metastasis. EMBO Journal (2016) Kondo N, Ueda, Y, Kita T, Ozawa, M, Tomiyama, T, Yasuda, K, Lim DS ... & Kinashi, T. NDR1-dependent regulation of kindlin-3 controls high-affinity LFA-1 binding and immune synapse organization. Molecular and Cellular Biology (2017)

28. Kim T*, Hwang D*, Lee D, Kim JH, Kim SY, Lim DS. MRTF potentiates TEAD-YAP transcriptional activity causing cancer metastasis. EMBO Journal (2016)

29. Kim HB#, Kim MC#, Park YS, Park I, Kim TH, Yang SY, Cho CJ, Hwang DH, Jung JH, Markowitz SD, Hwang SW, Yang SK, Lim DS*, Myung SJ*. Prostaglandin E2 and YAP form a positive feedback loop that promotes colon regeneration and tumorigenesis. Gastroenterology (2016) *Co-corresponding authors in this paper.

30. Seo EJ, Kim WY, Hur J, Kim H, Nam SA, Choi A, Kim YM, Park SH, Chung C, Kim J, Min S, Myung SJ, Lim DS*, Kim YK*.The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Scientific Reports, (2016) 6.10.1038/srep31931 *Co-corresponding authors in this paper.

31. Lee DH, Park JO, Kim TS, Kim SK, Kim T, Kim M, Park GS, Kim JH, Kuninaka S, Olson EN, Saya H, Kim SY, Lee H, Lim DS. LATS-YAP/TAZ controls lineage specification by regulating TGF-beta signaling and Hnf4-alpha expression during liver development. Nat. Comm. (2016) 7:11961

32. Park GS, Oh HY, Kim M, Kim T, Johnson RL, Irvine KD, Lim DS. An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2. Oncotarget (2016) Vol.7, No.17 pp.24063-24075

33. Kim T, Yang SJ, Hwang D, Song J, Kim M, Kim SK, Kang K, Ahn J, Lee D, Kim M, Kim S, Koo JS, Koh SS, Kim SY, Lim DS. A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness. Nat. Comm. (2015) 6:10186

34. Kim M, Kim M, Park SJ, Lee CJ, Lim DS. Role of Angiomotin‐like 2 mono‐ubiquitination on YAP inhibition. EMBO Rep. (2015) Nov 23;17:64-78

35. Kim M, Kim T, Johnson RL, Lim DS. Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ. Cell Rep. (2015) Apr 14;11(2):270-82.

36. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. (2015) Mar 9. doi: 10.1038/ncb3111. [Epub ahead of print]

37. Kim MJ, Kim MC, Lee MS, Kim CH, Lim DS. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis..Nat Commun.(2014) Nov 4;5:5370.

38. Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D, Sadoshima J.A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.Nat Commun.(2014) Feb 14;5:3315.

39. Lee JK, Shin JJ, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, and Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci USA (2013) 110.29: 12066-12071

40. Kim SK, Kim H, Lee DH, Kim TS, Kim T, Chung C, Koh GY, Kim H, & Lim DS. Reversing the Intractable Nature of Pancreatic Cancer by Selectively Targeting ALDH-High, Therapy-Resistant Cancer Cells. PLOS ONE 8.10 (2013): e78130.

41. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re D, Zablocki D, Hsu D, Lim DS, Isobe M, and Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nature medicine (2013).

42. Seo E, Basu-Roy U, Gunaratne PH, Coarfa C, Lim DS, Basilico C, Mansukhani A. SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage. Cell Reports, Volume 3, Issue 6, 27 June 2013, Pages 2075–2087

43. Kim MC, Kim MJ and Lim DS. cAMP/PKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. The EMBO Journal. 2013 May. doi:10.1038/emboj.2013.102

44. Chung C, Kim T, Kim M, Kim M, Song H, Kim T, Seo E, Lee S, Kim H, Yoo G, Lee D, Hwang D, Kinashi T, Kim J and Lim DS. Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci USA 2013, April. doi: 10.1073/pnas.1220603110

45. Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, et al. Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development. PLoS Genet 2013 9(3): e1003380. doi:10.1371

46. HW Lee, T Kyung, J Yoo, T Kim, C Chung et al. Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics. Nature Communications 2013. 4:1505 | DOI: 10.1038/ncomms2507

47. Ditacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R. Transcription Factors ER71/ETV2 and SOX9 Participate in a Positive Feedback Loop in Fetal and Adult Mouse Testis. J. Biol. Chem,2012 July 23657-23666.

48. Kim TS, Lee DH, Kim SK, Shin SY, Seo EJ, Lim DS. Mammalian sterile 20-like kinase 1 (Mst1) suppresses lymphoma development by promoting faithful chromosome segregation. Cancer Res. 2012 Aug 27. [Epub ahead of print]

49. Liu F, Kang I, Park C, Chang LW, Wang W, Lee D, Lim DS, Vittet D, Nerbonne JM, Choi K. ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood. 2012 Feb 17.[Epub ahead of print]

50. Song H, Kim H, Lee K, Lee DH, Kim TS, Song JY, Lee D, Choi D, Ko CY, Kim HS, Shin HI, Choi J, Park H, Park C, Jeong D and Lim DS. (2012) Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. The EMBO Journal 31, 1147 - 1159.

51. Bell DW, Sikdar N, Lee K-y, Price JC, Chatterjee R, et al. (2011) Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5. PLoS Genet 7(8): e1002245. doi:10.1371/journal.pgen.1002245

52. Yun HJ, Yoon JH, Lee JK, Noh KT, Yoon KW, Oh SP, Oh HJ, Chae JS, Hwang SG, Kim EH, Maul GG, Lim DS, Choi EJ. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011 May 13;30(12):2465-76.

53. Lee D, Kim T, Lim DS. The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells. 2011 Mar;29(3):539-48.

54. Lee SJ, Lee MH, Kim DW, Lee S, Huang S, Ryu MJ, Kim YK, Kim SJ, Kim SJ, Hwang JH, Oh S, Cho H, Kim JM, Lim DS, Jo YS, Shong M. Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS One. 2011 Jan 13;6(1):e16180.

55. Park JD, Lee YS, Oh YK, Jung JG, Jung JG, Park YO, Myung KJ, Kim KH, Koh SS* and Lim DS*. Pancreatic adenocarcinoma up-regulated factor (PAUF) promotes metastasis by regulating TLR/CXCR4 activation Oncogene. 2011 Jan 13;30(2):201-11. *Co-corresponding authors in this paper.

56. Song JY, Lee JH, Joe CO, Lim DS, Chung JH. Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency-induced hepatocarcinogenesis. Biochem Biophys Res Commun. 2011 Jan 14;404(2):728-34.

57. Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB. J Biol Chem. 2010 Nov 5;285(45):35029-38.

58. Male-like sexual behavior of female mouse lacking fucose mutarotase. Park D, Choi D, Lee J, Lim DS, Park C. BMC Genet. 2010 Jul 7;11:62

59. Lee KP, Lee JH, Kim TS, Kim TH, Park HD, Byun JS, Kim MC, Jeong WI, Calvisi D, Kim JM, and Lim DS. The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis, Proc Natl Acad Sci USA. 2010 107(18):8248-53.

60. Oh HJ, Kim MJ, Song SJ, Kim T, Lee D, Kwon SH, Choi EJ,and Lim DS, MST1 Limits the Kinase Activity of Aurora B to Promote Stable Kinetochore-Microtubule Attachment, Current Biology. 2010 20: 1–7, March 9

61. Song H, Oh S, Oh HJ, Lim DS., Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity, Biochem Biophys Res Commun. 2010 391: 969-973.

62. Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB, Kim JM, Lim DS*, Koh SS*., PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression, Oncogene. 2010 29: 56–67. *Co-corresponding authors in this paper.

63. Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM, SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis, GASTROENTEROLOGY. 2009 137: 1816-26.

64. Choi J*, Oh S*, Lee D, Oh HJ, Park JY, Lee SB, Lim DS, Mst1-FoxO signaling protects naïve T lymphocytes from cellular oxidative stress in mice, PLoS ONE. 2009 4(11): e8011.

65. Song SJ, Kim SJ, Song MS and Lim DS, Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody, Cancer Res. 2009 69(22): 8540–4.

66. Oh S*, Lee D*, Kim T*, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS and Lim DS, Crucial Role for Mst1 and Mst2 Kinases in Early Embryonic Development of the Mouse, Mol Cell Biol. 2009 69(6): 2314-23.

67. Song SJ, Song MS, Kim SJ, Kim SY, Kwon SH, Kim JG, Calvisi DF, Kang D, Lim DS., Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity., Cancer Res. 2009 69(6):2314-23.

68. Koh W, Park BW, Lee SH, Lee Miae, Lee D, Lim DS, Lee SJ, Cancer-Upregulated Gene 2 (CUG2), a New Component of Centromere Complex, Is Required for Kinetochore Function, Mol Cells. 2009 27(6): 697-701.

69. Noh EJ, Lim DS, Lee JS, A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death, Biochem Biophys Res Commun. 2009 378(3):332-7.

70. Noh EJ, Lim DS, Jeong G, Lee JS, An HDAC inhibitor, trichostatin A, induces a delay at G(2)/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner, Biochem Biophys Res Commun. 2009 378(3):326-31.

71. Jang MS, Sul JW, Choi BJ, Lee SJ, Suh JH, Kim NS, Kim WH, Lim DS, Lee CW, Kim E, Negative Feedback Regulation of Aurora-A via Phosphorylation of Fas-associated Factor-1, J Biol Chem. 2008 283(47):32344-51.

72. Song MS *, Song SJ *, Kim SY, Oh HJ and Lim D.-S. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008 Jul 9;27(13):1863-74. *These authors contributed equally to this work.

73. Lee D, Park C , Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim D.-S*, Choi K*. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008, 2(5):497-507. *Co-corresponding authors in this paper.

74. Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM and Lim D.-S. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42.

75. Song MS *, Song SJ *, Kim SJ, Nakayama K, SNakayama KI, and Lim D.-S. Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition. Oncogene. 2008 May 15;27(22):3176-85. *: These authors contributed equally to this work.

76. Jung H *, Lee KP *, Park SJ, Park JH, Jang YS, Choi SY, Jung JG, Jo K, Park DY, Yoon JH, Park JH, Lim DS, Hong GR, Choi C, Park YK, Lee JW, Hong HJ, Kim S, Park YW., TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition., Oncogene. 2008 27(18):2635-47.

77. Hwang E, Ryu KS, Pääkkönen K, Güntert P, Cheong HK, Lim D.-S., Lee JO, Jeon YH, Cheong C. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9236-41.

78. Lee H, Lee DJ, Oh SP, Park HD, Nam HH, Kim JM and Lim D.-S. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol. Cell. Biol. 2006 July . 26(14):5373-81

79. Lee JH, Lim D.-S, Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response. FEBS J. 2006 Apr; 273(8):1630-6.

80. Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, Lee JH, Im CR, Lee JO, Yonehara S, Lim DS. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006 Mar 1;66(5):2562-9.

81. Choi N, Son DS, Song I, Lee HS, Lim YS, Song MS, Lim D.-S, Lee J, Kim H, Kim J. .RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer. Int J Cancer. 2005 Jul 1;115(4):575-81.

82. Song MS, Chang JS, Song SJ, Yang TH, Lee H, Lim D.-S. The Centrosomal Protein RAS Association Domain Family Protein 1A (RASSF1A)-binding Protein 1 Regulates Mitotic Progression by Recruiting RASSF1A to Spindle Poles. J Biol Chem. 2005 Feb 4;280(5):3920-7.

83. Song MS and Lim D.-S. (2004). Control of APC-Cdc20 by the Tumor Suppressor RASSF1A. Cell Cycle 3. May 3(5):574-6.

84. Jang ER, Lee JH, Lim D.-S. and Lee JS. Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns. J Cancer Res Clin Oncol. 2004 Apr;130(4):225-34.

85. Garg R, Callens S, Lim DS, Canman CE, Kastan MB, Xu B., Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation, Mol Cancer Res. 2004 2(6):362-9.

86. Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim D.-S. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol. 2004 Feb;6(2):129-37.

87. Lee JH, Xu B, Lee CH, Ahn YJ, Song MS, Lee H, Canman CE, Lee JS, Kastab MB, Lim D.-S. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol. Cancer Res. 2003 Jul;1(9):674-81.

88. Choi J, Chang JS, Song MS, Ahn BY, Park Y, Lim D.-S, Han YS, Association of hepatitis B virus polymerase with promyelocytic leukemia nuclear bodies mediated by the S100 family protein p11, Biochem Biophys Res Commun. 2003 305(4):1049-56

89. Xu, B. Kim, S.T, Lim, D.-S. and Kastan, M.B. Two Molecular Distinct G2/M Checkpoints. Mol. Cell. Biol 2002. 22: 1049-1059

90. Kastan, M.B., Lim,D.-S., Kim, S.T., Yang D. ATM-A key determinant of multiple cellular responses to irradiation Acta Oncologica 2001 40: 686-688

91. Kastan, M.B., Lim,D.-S., Kim, S.T., Xu, B., Canman, C, Multiple Signaling Pathways Involving ATM. Cold Spring Harbor Symposia ON QUANTITATIVE BIOLOGY 2001 LXV; 521-526.

92. Kastan MB and Lim, D.-S. Many functions and many substrates of ATM. Nature Review Molecular Cell Biology . 1 179-186 2000.

93. Ziv Y, Banin S, Lim D.-S, Canman CE, Kastan MB, Shiloh Y. Expression and assay of recombinant ATM. Methods Mol Biol. 2000;99:99-108.

94. Lim, D.-S., Vogel,H., Sands, T.A., Platt, K.A., and Hasty,P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol. Cell. Biol. 2000 20:3772-3780

95. Lim, D.-S*., Kim, S.T*, Xu, B., Maser, R.S. Lin, J., Petrini, P. and Kastan, M.B. ATM phosphorylates p95/nbs1 in an S-phase Checkpoint pathway. Nature. 2000 404: 613-617 Lim* is the first co-author in this paper

96. Pandita TK, Lieberman HB, Lim D.-S., Dhar S, Zheng W, Taya Y, Kastan MB, Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene 2000 19(11):1386-91

97. 78. Kim, S.T. *, Lim, D.-S*,Canman, C., and Kastan,M.B. Substrate Specificities and Identification of Substrates of ATM kinase Family members. J. Biol. Chem. 1999 274:37538-37543 Lim* is the first co-author in this paper.

98. Bogue, M.A., Lim, D.-S., Karsenty, G., Finegold, M., and Hasty,P. Deletion of Ku86 causes early onset of senescence in mice. Proc. Natl. Acad. Sci 1999. 96: 10770-10775

99. Kastan M.B., Lim, D-S, Kim, S.T., and Canman, C. Roles of TP53 and ATM in Radiation Responses. The Biology of Radiation Responses Radiation Research Vol II; 1999, July :p413-415

100. Kirsh, G.D., Doseff, A., Chau, N., Lim, D.-S., Souza-Pinta, N., Hansford, R., Kastan, M.B., Lazebnik., Y., Hardwick, J.M. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c J. Biol. Chem, 1999, 274: 21155-21161

101. Canman, C.E. and Lim, D.-S. The role of ATM in DNA damage response and cancer Oncogene 1998, 17:3301-3308.

102. Canman, C.E., Lim, D.-S., Cimprich, K.A., Taya, Y., Tamai., Sakaguchi, K., Appella, E.,Kastan, M.B., and Siliciano, J.D. (1998). Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679.

103. Lim, D.-S. Kirsch, D. G., Canman, C. E., Ahn, J-H.,Ziv, Y., Newman, L. S., Darnell, R. B., Shiloh, Y., Kastan, M. B.(1998) ATM binds to beta-Adaptin in cytoplasmic vesicles. Proc. Natl. Acad. Sci. 95: 10146-10151.

104. Sharan, S.K., Morimatsu, M., Albrecht, U., Lim, D.-S., Regal,E., Dinh. C., Sands, A., Eicheles, G., Hasty, P., and Bradley, A. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 (Article). Nature 386 24: 804- 810

105. Lim ,D.-S. and Hasty , P. (1996) A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16: 7133-7143.

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