Publications

DAE-SIK LIM‬ - ‪Google Scholar‬ 

1. Choi S, Kang JG, Tran YTH, Jeong SH, Park KY, Shin H, Kim YH, Park M, Nahmgoong H, Seol T, Jeon H, Kim Y, Park S, Kim HJ, Kim MS, Li X, Bou Sleiman M, Lee E, Choi J, Eisenbarth D, Lee SH, Cho S, Moore DD, Auwerx J, Kim IY, Kim JB, Park JE, Lim DS, Suh JM. Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass. Nat Metab. 2024 May;6(5):847-860. doi: 10.1038/s42255-024-01045-4. Epub 2024 May 29. PMID: 38811804; PMCID: PMC11136666.

2. Ku B, Eisenbarth D, Baek S, Jeong TK, Kang JG, Hwang D, Noh MG, Choi C, Choi S, Seol T, Kim H, Kim YH, Woo SM, Kong SY, Lim DS. PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. Cell Rep Med. 2024 Mar 19;5(3):101461. doi: 10.1016/j.xcrm.2024.101461. Epub 2024 Mar 8. PMID: 38460517; PMCID: PMC10983040.

3. Jeong DJ, Um JH, Kim YY, Shin DJ, Im S, Lee KM, Lee YH, Lim DS, Kim D, Yun J. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress. Exp Mol Med. 2024 Mar;56(3):674-685. doi: 10.1038/s12276-024-01198-y. Epub 2024 Mar 5. PMID: 38443598; PMCID: PMC10984967.

4. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. Two Hippo signaling modules orchestrate liver size and tumorigenesis. EMBO J. 2023 Nov 15;42(22):e115749. doi: 10.15252/embj.2023115749. Epub 2023 Oct 17. Erratum for: EMBO J. 2023 Jun 1;42(11):e112126. doi: 10.15252/embj.2022112126. PMID: 37849424; PMCID: PMC10646547.

5. Kim MK, Han SH, Park TG, Song SH, Lee JY, Lee YS, Yoo SY, Chi XZ, Kim EG, Jang JW, Lim DS, Wijnen AJV, Lee JW, Bae SC. The TGFβ→TAK1→LATS→YAP1 Pathway Regulates the Spatiotemporal Dynamics of YAP1. Mol Cells. 2023 Oct 31;46(10):592-610. doi: 10.14348/molcells.2023.0088. Epub 2023 Sep 13. PMID: 37706312; PMCID: PMC10590711.

6. Park A, Kim KE, Park I, Lee SH, Park KY, Jung M, Li X, Sleiman MB, Lee SJ, Kim DS, Kim J, Lim DS, Woo EJ, Lee EW, Han BS, Oh KJ, Lee SC, Auwerx J, Mun JY, Rhee HW, Kim WK, Bae KH, Suh JM. Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice. Nat Commun. 2023 Jun 23;14(1):3746. doi: 10.1038/s41467-023-39106-z. PMID: 37353518; PMCID: PMC10290150.

7. Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX. Two Hippo signaling modules orchestrate liver size and tumorigenesis. EMBO J. 2023 Jun 1;42(11):e112126. doi: 10.15252/embj.2022112126. Epub 2023 Mar 15. Erratum in: EMBO J. 2023 Nov 15;42(22):e115749. doi: 10.15252/embj.2023115749. PMID: 36919851; PMCID: PMC10233384.

8. Masgrau-Alsina S, Wackerbarth LM, Lim DS, Sperandio M. MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis. Front Immunol. 2022 Dec 23;13:1038936. doi: 10.3389/fimmu.2022.1038936. PMID: 36618429; PMCID: PMC9816424.

9. Kim J, Park KY, Choi S, Ko UH, Lim DS, Suh JM, Shin JH. Ceiling culture chip reveals dynamic lipid droplet transport during adipocyte dedifferentiation via actin remodeling. Lab Chip. 2022 Oct 11;22(20):3920-3932. doi: 10.1039/d2lc00428c. PMID: 36097851.

10. Sohn HA, Lee DC, Park A, Kang M, Yoon BH, Lee CH, Kim YH, Oh KJ, Kim CY, Park SH, Koo H, Kim HC, Yoon WK, Lim DS, Kim D, Park KC, Yeom YI. Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers. Cells. 2022 May 4;11(9):1536. doi: 10.3390/cells11091536. PMID: 35563842; PMCID: PMC9103136.

11. Jeon HY, Choi J, Kraaier L, Kim YH, Eisenbarth D, Yi K, Kang JG, Kim JW, Shim HS, Lee JH, Lim DS. Airway secretory cell fate conversion via YAP- mTORC1-dependent essential amino acid metabolism. EMBO J. 2022 Apr 19;41(8):e109365. doi: 10.15252/embj.2021109365. Epub 2022 Mar 14. PMID: 35285539; PMCID: PMC9016350.

12. Hwang D, Kim M, Kim S, Kwon MR, Kang YS, Kim D, Kang HC, Lim DS. AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation. Life Sci Alliance. 2021 Aug 17;4(10):e202000953. doi: 10.26508/lsa.202000953. PMID: 34404733; PMCID: PMC8372784.

13. Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, Dobrowolski A, Ghawali J, Ruhlandt M, Gorrepati KDD, Azizi Z, Lim DS, Maedler K, Ardestani A. The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun. 2021 Aug 13;12(1):4928. doi: 10.1038/s41467-021-25145-x. PMID: 34389720; PMCID: PMC8363615.

14. Roh KH, Lee Y, Yoon JH, Lee D, Kim E, Park E, Lee IY, Kim TS, Song HK, Shin J, Lim DS, Choi EJ. TRAF6-mediated ubiquitination of MST1/STK4 attenuates the TLR4-NF-κB signaling pathway in macrophages. Cell Mol Life Sci. 2021 Mar;78(5):2315-2328. doi: 10.1007/s00018-020-03650-4. Epub 2020 Sep 25. PMID: 32975614; PMCID: PMC11071754.

15. Park J, Eisenbarth D, Choi W, Kim H, Choi C, Lee D, Lim DS. YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice. Cancer Res. 2020 Nov 1;80(21):4768-4779. doi: 10.1158/0008-5472.CAN-20-0907. Epub 2020 Sep 8. PMID: 32900774.

16. Park J, Kim JS, Nahm JH, Kim SK, Lee DH, Lim DS. WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice. Mol Cells. 2020 May 31;43(5):491-499. doi: 10.14348/molcells.2020.0093. PMID: 32451369; PMCID: PMC7264477.

17. Choi SY, Bae H, Jeong SH, Park I, Cho H, Hong SP, Lee DH, Lee CK, Park JS, Suh SH, Choi J, Yang MJ, Jang JY, Onder L, Moon JH, Jeong HS, Adams RH, Kim JM, Ludewig B, Song JH, Lim DS, Koh GY. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020 Jan 24;11(1):519. doi: 10.1038/s41467-020-14293-1. PMID: 31980640; PMCID: PMC6981200.

18. Tang F, Gao R, Jeevan-Raj B, Wyss CB, Kalathur RKR, Piscuoglio S, Ng CKY, Hindupur SK, Nuciforo S, Dazert E, Bock T, Song S, Buechel D, Morini MF, Hergovich A, Matthias P, Lim DS, Terracciano LM, Heim MH, Hall MN, Christofori G. LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function. Nat Commun. 2019 Dec 17;10(1):5755. doi: 10.1038/s41467-019-13591-7. PMID: 31848340; PMCID: PMC6917744.

19. Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes Dev. 2020 Jan 1;34(1-2):72-86. doi: 10.1101/gad.331546.119. Epub 2019 Dec 12. PMID: 31831627; PMCID: PMC6938666.

20. Tran THY, Yang DW, Kim M, Lee DH, Gai M, Di Cunto F, Choi KW, Lim DS. Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif. J Mol Cell Biol. 2019 Dec 23;11(11):1006-1017. doi: 10.1093/jmcb/mjz013. PMID: 30865227; PMCID: PMC6927243.

21. Kim YH, Choi J, Yang MJ, Hong SP, Lee CK, Kubota Y, Lim DS, Koh GY. A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis. Nat Commun. 2019 Feb 19;10(1):838. doi: 10.1038/s41467-019-08773-2. PMID: 30783090; PMCID: PMC6381131.

22. Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. PMID: 30582455; PMCID: PMC6645688.

23. Cho H, Kim J, Ahn JH, Hong YK, Mäkinen T, Lim DS, Koh GY. YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis. Circ Res. 2019 Jan 18;124(2):225-242. doi: 10.1161/CIRCRESAHA.118.313707. PMID: 30582452.

24. Bagherzadeh Yazdchi S, Witalis M, Meli AP, Leung J, Li X, Panneton V, Chang J, Li J, Nutt SL, Johnson RL, Lim DS, Gu H, King IL, Suh WK. Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity. J Immunol. 2019 Jan 1;202(1):69-78. doi: 10.4049/jimmunol.1701407. Epub 2018 Nov 26. PMID: 30478091; PMCID: PMC6310088.

25. Bae JS, Jeon Y, Kim SM, Jang JY, Park MK, Kim IH, Hwang DS, Lim DS, Lee H. Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling. Cell Death Dis. 2018 Oct 22;9(11):1083. doi: 10.1038/s41419-018-1138-0. PMID: 30349003; PMCID: PMC6197243.

26. Hagenbeek TJ, Webster JD, Kljavin NM, Chang MT, Pham T, Lee HJ, Klijn C, Cai AG, Totpal K, Ravishankar B, Yang N, Lee DH, Walsh KB, Hatzivassiliou G, de la Cruz CC, Gould SE, Wu X, Lee WP, Yang S, Zhang Z, Gu Q, Ji Q, Jackson EL, Lim DS, Dey A. The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors. Sci Signal. 2018 Sep 11;11(547):eaaj1757. doi: 10.1126/scisignal.aaj1757. PMID: 30206136.

27. Kim J, Hong CM, Park SM, Shin DH, Kim JY, Kwon SM, Kim JH, Kim CD, Lim DS, Lee D. SURF4 has oncogenic potential in NIH3T3 cells. Biochem Biophys Res Commun. 2018 Jul 7;502(1):43-47. doi: 10.1016/j.bbrc.2018.05.116. Epub 2018 May 21. PMID: 29777698.

28. Jeong SH, Lim DS. Insulin receptor substrate 2: a bridge between Hippo and AKT pathways. BMB Rep. 2018 May;51(5):209-210. doi: 10.5483/bmbrep.2018.51.5.095. PMID: 29699606; PMCID: PMC5988573.

29. Choi W, Kim J, Park J, Lee DH, Hwang D, Kim JH, Ashktorab H, Smoot D, Kim SY, Choi C, Koh GY, Lim DS. YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC. Cancer Res. 2018 Jun 15;78(12):3306-3320. doi: 10.1158/0008-5472.CAN-17-3487. Epub 2018 Apr 18. PMID: 29669762.

30. Hong EH, Kim JY, Kim JH, Lim DS, Kim M, Kim JY. BIG2-ARF1-RhoA-mDia1 Signaling Regulates Dendritic Golgi Polarization in Hippocampal Neurons. Mol Neurobiol. 2018 Oct;55(10):7701-7716. doi: 10.1007/s12035-018-0954-7. Epub 2018 Feb 17. PMID: 29455446.

31. Jeong SH, Kim HB, Kim MC, Lee JM, Lee JH, Kim JH, Kim JW, Park WY, Kim SY, Kim JB, Kim H, Kim JM, Choi HS, Lim DS. Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. J Clin Invest. 2018 Mar 1;128(3):1010-1025. doi: 10.1172/JCI95802. Epub 2018 Feb 5. PMID: 29400692; PMCID: PMC5824861.

32. Lee DH, Kim TS, Lee D, Lim DS. Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition. Sci Rep. 2018 Jan 17;8(1):942. doi: 10.1038/s41598-018-19637-y. PMID: 29343826; PMCID: PMC5772645.

33. Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW. Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Dev Cell. 2018 Jan 8;44(1):13-28.e3. doi: 10.1016/j.devcel.2017.11.011. Epub 2017 Dec 14. PMID: 29249622; PMCID: PMC5760287.

34. Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, Koh GY. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017 Sep 1;127(9):3441-3461. doi: 10.1172/JCI93825. Epub 2017 Aug 14. PMID: 28805663; PMCID: PMC5669570.

35. Lee BS, Park DI, Lee DH, Lee JE, Yeo MK, Park YH, Lim DS, Choi W, Lee DH, Yoo G, Kim HB, Kang D, Moon JY, Jung SS, Kim JO, Cho SY, Park HS, Chung C. Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI- resistant lung adenocarcinoma. Biochem Biophys Res Commun. 2017 Sep 16;491(2):493-499. doi: 10.1016/j.bbrc.2017.07.007. Epub 2017 Jul 3. PMID: 28684311.

36. Jang W, Kim T, Koo JS, Kim SK, Lim DS. Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. EMBO J. 2017 Sep 1;36(17):2510-2528. doi: 10.15252/embj.201696089. Epub 2017 Jul 3. PMID: 28673931; PMCID: PMC5579353.

37. Yoo G, Kim T, Chung C, Hwang DS, Lim DS. The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3β-mediated TAZ destabilization. Biochem Biophys Res Commun. 2017 Aug 26;490(3):650-656. doi: 10.1016/j.bbrc.2017.06.092. Epub 2017 Jun 17. PMID: 28634071.

38. Robertson A, Mohamed TM, El Maadawi Z, Stafford N, Bui T, Lim DS, Cartwright EJ, Oceandy D. Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Res. 2017 Apr;20:42-49. doi: 10.1016/j.scr.2017.02.011. Epub 2017 Feb 27. PMID: 28257933; PMCID: PMC5376382.

39. Kondo N, Ueda Y, Kita T, Ozawa M, Tomiyama T, Yasuda K, Lim DS, Kinashi T. NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization. Mol Cell Biol. 2017 Mar 31;37(8):e00424-16. doi: 10.1128/MCB.00424-16. PMID: 28137909; PMCID: PMC5376635.

40. Kim T, Hwang D, Lee D, Kim JH, Kim SY, Lim DS. MRTF potentiates TEAD-YAP transcriptional activity causing metastasis. EMBO J. 2017 Feb 15;36(4):520-535. doi: 10.15252/embj.201695137. Epub 2016 Dec 27. PMID: 28028053; PMCID: PMC5694947.

41. Kim HB, Kim M, Park YS, Park I, Kim T, Yang SY, Cho CJ, Hwang D, Jung JH, Markowitz SD, Hwang SW, Yang SK, Lim DS, Myung SJ. Prostaglandin E₂ Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice. Gastroenterology. 2017 Feb;152(3):616-630. doi: 10.1053/j.gastro.2016.11.005. Epub 2016 Nov 15. PMID: 27864128; PMCID: PMC5285392.

42. Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 2016 Nov 1;126(11):4125-4139. doi: 10.1172/JCI87043. Epub 2016 Oct 4. PMID: 27701149; PMCID: PMC5096904.

43. Seo E, Kim WY, Hur J, Kim H, Nam SA, Choi A, Kim YM, Park SH, Chung C, Kim J, Min S, Myung SJ, Lim DS, Kim YK. The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis. Sci Rep. 2016 Aug 23;6:31931. doi: 10.1038/srep31931. PMID: 27550469; PMCID: PMC4994041.

44. Chung C, Yoo G, Kim T, Lee D, Lee CS, Cha HR, Park YH, Moon JY, Jung SS, Kim JO, Lee JC, Kim SY, Park HS, Park M, Park DI, Lim DS, Jang KW, Lee JE. The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation. Biochem Biophys Res Commun. 2016 Oct 14;479(2):152-158. doi: 10.1016/j.bbrc.2016.07.111. Epub 2016 Jul 28. PMID: 27475501.

45. Lee DH, Park JO, Kim TS, Kim SK, Kim TH, Kim MC, Park GS, Kim JH, Kuninaka S, Olson EN, Saya H, Kim SY, Lee H, Lim DS. LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development. Nat Commun. 2016 Jun 30;7:11961. doi: 10.1038/ncomms11961. PMID: 27358050; PMCID: PMC4931324.

46. Kim T, Lim DS. The SRF-YAP-IL6 axis promotes breast cancer stemness. Cell Cycle. 2016 May 18;15(10):1311-2. doi: 10.1080/15384101.2016.1161994. PMID: 27184334; PMCID: PMC4916404.

47. Lee JE, Park HS, Lee D, Yoo G, Kim T, Jeon H, Yeo MK, Lee CS, Moon JY, Jung SS, Kim JO, Kim SY, Park DI, Park YH, Lee JC, Oh IJ, Lim DS, Chung C. Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance. Biochem Biophys Res Commun. 2016 May 20;474(1):154-160. doi: 10.1016/j.bbrc.2016.04.089. Epub 2016 Apr 20. PMID: 27105908.

48. Park GS, Oh H, Kim M, Kim T, Johnson RL, Irvine KD, Lim DS. An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2. Oncotarget. 2016 Apr 26;7(17):24063-75. doi: 10.18632/oncotarget.8211. PMID: 27006470; PMCID: PMC5029684.

49. Kim T, Yang SJ, Hwang D, Song J, Kim M, Kyum Kim S, Kang K, Ahn J, Lee D, Kim MY, Kim S, Seung Koo J, Seok Koh S, Kim SY, Lim DS. A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness. Nat Commun. 2015 Dec 16;6:10186. doi: 10.1038/ncomms10186. PMID: 26671411; PMCID: PMC4703869.

50. Kim M, Kim M, Park SJ, Lee C, Lim DS. Role of Angiomotin-like 2 mono- ubiquitination on YAP inhibition. EMBO Rep. 2016 Jan;17(1):64-78. doi: 10.15252/embr.201540809. Epub 2015 Nov 23. PMID: 26598551; PMCID: PMC4718409.

51. Park C, Lee TJ, Bhang SH, Liu F, Nakamura R, Oladipupo SS, Pitha-Rowe I, Capoccia B, Choi HS, Kim TM, Urao N, Ushio-Fukai M, Lee DJ, Miyoshi H, Kim BS, Lim DS, Apte RS, Ornitz DM, Choi K. Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):86-96. doi: 10.1161/ATVBAHA.115.306430. Epub 2015 Nov 19. PMID: 26586661; PMCID: PMC4690812.

52. Kim SK, Kim H, Koh GY, Lim DS, Yu DY, Kim MD, Park MS, Lim JS. Mouse Hepatic Tumor Vascular Imaging by Experimental Selective Angiography. PLoS One. 2015 Jul 1;10(7):e0131687. doi: 10.1371/journal.pone.0131687. PMID: 26131558; PMCID: PMC4489182.

53. Choi S, Lim DS, Chung J. Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila. PLoS Genet. 2015 May 21;11(5):e1005263. doi: 10.1371/journal.pgen.1005263. PMID: 25996931; PMCID: PMC4440640.

54. Kim M, Kim T, Johnson RL, Lim DS. Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ. Cell Rep. 2015 Apr 14;11(2):270-82. doi: 10.1016/j.celrep.2015.03.015. Epub 2015 Apr 2. PMID: 25843714.

55. Lee J, Youn BU, Kim K, Kim JH, Lee DH, Seong S, Kim I, Han SH, Che X, Choi JY, Park YW, Kook H, Kim KK, Lim DS, Kim N. Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation. J Bone Miner Res. 2015 Sep;30(9):1597-607. doi: 10.1002/jbmr.2503. Epub 2015 May 31. PMID: 25761670.

56. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr;17(4):500-10. doi: 10.1038/ncb3111. Epub 2015 Mar 9. PMID: 25751140; PMCID: PMC4380774.

57. Kim M, Kim M, Lee MS, Kim CH, Lim DS. The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis. Nat Commun. 2014 Nov 4;5:5370. doi: 10.1038/ncomms6370. PMID: 25367221.

58. Zi M, Maqsood A, Prehar S, Mohamed TM, Abou-Leisa R, Robertson A, Cartwright EJ, Ray SG, Oh S, Lim DS, Neyses L, Oceandy D. The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy. J Biol Chem. 2014 Aug 29;289(35):24275-88. doi: 10.1074/jbc.M114.562405. Epub 2014 Jul 17. PMID: 25035424; PMCID: PMC4148857.

59. Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D, Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315. doi: 10.1038/ncomms4315. PMID: 24525530; PMCID: PMC3962829.

60. Kim SK, Kim H, Lee DH, Kim TS, Kim T, Chung C, Koh GY, Kim H, Lim DS. Reversing the intractable nature of pancreatic cancer by selectively targeting ALDH-high, therapy-resistant cancer cells. PLoS One. 2013 Oct 23;8(10):e78130. doi: 10.1371/journal.pone.0078130. PMID: 24194908; PMCID: PMC3806801.

61. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013 Nov;19(11):1478-88. doi: 10.1038/nm.3322. Epub 2013 Oct 20. PMID: 24141421; PMCID: PMC3823824.

62. Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee AC, Lee J, Kowall NW, Ryu H, Lim DS, Choi EJ. MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12066-71. doi: 10.1073/pnas.1300894110. Epub 2013 Jul 1. PMID: 23818595; PMCID: PMC3718122.

63. Seo E, Basu-Roy U, Gunaratne PH, Coarfa C, Lim DS, Basilico C, Mansukhani A. SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo- adipo lineage. Cell Rep. 2013 Jun 27;3(6):2075-87. doi: 10.1016/j.celrep.2013.05.029. Epub 2013 Jun 20. PMID: 23791527; PMCID: PMC5053763.

64. Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, Lee S, Lim DS. cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 2013 May 29;32(11):1543-55. doi: 10.1038/emboj.2013.102. Epub 2013 May 3. PMID: 23644383; PMCID: PMC3671250.

65. Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS. Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7. doi: 10.1073/pnas.1220603110. Epub 2013 Apr 25. PMID: 23620511; PMCID: PMC3651464.

66. Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013 Mar;9(3):e1003380. doi: 10.1371/journal.pgen.1003380. Epub 2013 Mar 21. PMID: 23555292; PMCID: PMC3605093.

67. Lee HW, Kyung T, Yoo J, Kim T, Chung C, Ryu JY, Lee H, Park K, Lee S, Jones WD, Lim DS, Hyeon C, Heo WD, Yoon TY. Real-time single-molecule co- immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics. Nat Commun. 2013;4:1505. doi: 10.1038/ncomms2507. PMID: 23422673; PMCID: PMC3586730.

68. Clark GJ, Baksh S, Latif F, Lim DS. RASSF Family Proteins. Mol Biol Int. 2012;2012:938916. doi: 10.1155/2012/938916. Epub 2012 Dec 10. PMID: 23304503; PMCID: PMC3523567.

69. Chae JS, Gil Hwang S, Lim DS, Choi EJ. Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1. Free Radic Biol Med. 2012 Dec 15;53(12):2335-43. doi: 10.1016/j.freeradbiomed.2012.10.527. Epub 2012 Oct 17. PMID: 23085515.

70. Kim TS, Lee DH, Kim SK, Shin SY, Seo EJ, Lim DS. Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation. Cancer Res. 2012 Oct 15;72(20):5386-95. doi: 10.1158/0008-5472.CAN-11-3956. Epub 2012 Aug 27. PMID: 22926556.

71. DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R. Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 2012 Jul 6;287(28):23657-66. doi: 10.1074/jbc.M111.320101. Epub 2012 May 21. PMID: 22613723; PMCID: PMC3390640.

72. Liu F, Kang I, Park C, Chang LW, Wang W, Lee D, Lim DS, Vittet D, Nerbonne JM, Choi K. ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood. 2012 Apr 5;119(14):3295-305. doi: 10.1182/blood-2012-01-403766. Epub 2012 Feb 17. PMID: 22343916; PMCID: PMC3321855.

73. Song H, Kim H, Lee K, Lee DH, Kim TS, Song JY, Lee D, Choi D, Ko CY, Kim HS, Shin HI, Choi J, Park H, Park C, Jeong D, Lim DS. Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J. 2012 Mar 7;31(5):1147-59. doi: 10.1038/emboj.2011.480. Epub 2012 Jan 6. PMID: 22227519; PMCID: PMC3297990.

74. Bell DW, Sikdar N, Lee KY, Price JC, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL; NISC Comparative Sequencing Program; Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliot G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim DS, Myung K. Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genet. 2011 Aug;7(8):e1002245. doi: 10.1371/journal.pgen.1002245. Epub 2011 Aug 25. PMID: 21901109; PMCID: PMC3161924.

75. Yun HJ, Yoon JH, Lee JK, Noh KT, Yoon KW, Oh SP, Oh HJ, Chae JS, Hwang SG, Kim EH, Maul GG, Lim DS, Choi EJ. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011 May 13;30(12):2465-76. doi: 10.1038/emboj.2011.152. PMID: 21572393; PMCID: PMC3116283.

76. Lee D, Kim T, Lim DS. The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells. 2011 Mar;29(3):539-48. doi: 10.1002/stem.597. PMID: 21425416.

77. Lee SJ, Lee MH, Kim DW, Lee S, Huang S, Ryu MJ, Kim YK, Kim SJ, Kim SJ, Hwang JH, Oh S, Cho H, Kim JM, Lim DS, Jo YS, Shong M. Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS One. 2011 Jan 13;6(1):e16180. doi: 10.1371/journal.pone.0016180. PMID: 21249150; PMCID: PMC3020965.

78. Song JY, Lee JH, Joe CO, Lim DS, Chung JH. Retrotransposon-specific DNA hypomethylation and two-step loss-of-imprinting during WW45 haploinsufficiency- induced hepatocarcinogenesis. Biochem Biophys Res Commun. 2011 Jan 14;404(2):728-34. doi: 10.1016/j.bbrc.2010.12.052. Epub 2010 Dec 14. PMID: 21163252.

79. Park J, Kang SI, Lee SY, Zhang XF, Kim MS, Beers LF, Lim DS, Avruch J, Kim HS, Lee SB. Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem. 2010 Nov 5;285(45):35029-38. doi: 10.1074/jbc.M110.165506. Epub 2010 Sep 1. PMID: 20810663; PMCID: PMC2966117.

80. Park D, Choi D, Lee J, Lim DS, Park C. Male-like sexual behavior of female mouse lacking fucose mutarotase. BMC Genet. 2010 Jul 7;11:62. doi: 10.1186/1471-2156-11-62. PMID: 20609214; PMCID: PMC2912782.

81. Lee KP, Lee JH, Kim TS, Kim TH, Park HD, Byun JS, Kim MC, Jeong WI, Calvisi DF, Kim JM, Lim DS. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8248-53. doi: 10.1073/pnas.0912203107. Epub 2010 Apr 19. PMID: 20404163; PMCID: PMC2889558.

82. Oh HJ, Kim MJ, Song SJ, Kim T, Lee D, Kwon SH, Choi EJ, Lim DS. MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol. 2010 Mar 9;20(5):416-22. doi: 10.1016/j.cub.2009.12.054. Epub 2010 Feb 18. PMID: 20171103.

83. Yu KS, Lee Y, Kim CM, Park EC, Choi J, Lim DS, Chung YH, Koh SS. The protease inhibitor, elafin, induces p53-dependent apoptosis in human melanoma cells. Int J Cancer. 2010 Sep 1;127(6):1308-20. doi: 10.1002/ijc.25125. PMID: 20020498.

84. Song H, Oh S, Oh HJ, Lim DS. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem Biophys Res Commun. 2010 Jan 1;391(1):969-73. doi: 10.1016/j.bbrc.2009.11.175. Epub 2009 Dec 4. PMID: 19962960.

85. Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS. Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice. PLoS One. 2009 Nov 24;4(11):e8011. doi: 10.1371/journal.pone.0008011. PMID: 19956688; PMCID: PMC2776980.

86. Song SJ, Kim SJ, Song MS, Lim DS. Aurora B-mediated phosphorylation of RASSF1A maintains proper cytokinesis by recruiting Syntaxin16 to the midzone and midbody. Cancer Res. 2009 Nov 15;69(22):8540-4. doi: 10.1158/0008-5472.CAN-09-1554. Epub 2009 Nov 3. PMID: 19887622.

87. Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS. Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20. doi: 10.1128/MCB.00551-09. Epub 2009 Sep 28. PMID: 19786569; PMCID: PMC2786698.

88. Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM. SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. doi: 10.1053/j.gastro.2009.08.005. Epub 2009 Aug 15. PMID: 19686743.

89. Kim H, Lee M, Lee S, Park B, Koh W, Lee DJ, Lim DS, Lee S. Cancer- upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. Mol Cells. 2009 Jun 30;27(6):697-701. doi: 10.1007/s10059-009-0083-2. Epub 2009 Jun 12. PMID: 19533040.

90. Song SJ, Song MS, Kim SJ, Kim SY, Kwon SH, Kim JG, Calvisi DF, Kang D, Lim DS. Aurora A regulates prometaphase progression by inhibiting the ability of RASSF1A to suppress APC-Cdc20 activity. Cancer Res. 2009 Mar 15;69(6):2314-23. doi: 10.1158/0008-5472.CAN-08-3984. Epub 2009 Mar 10. PMID: 19276349.

91. Noh EJ, Lim DS, Lee JS. A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death. Biochem Biophys Res Commun. 2009 Jan 16;378(3):332-7. doi: 10.1016/j.bbrc.2008.11.079. Epub 2008 Nov 28. PMID: 19041848.

92. Noh EJ, Lim DS, Jeong G, Lee JS. An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner. Biochem Biophys Res Commun. 2009 Jan 16;378(3):326-31. doi: 10.1016/j.bbrc.2008.11.057. Epub 2008 Nov 25. PMID: 19038231.

93. Jang MS, Sul JW, Choi BJ, Lee SJ, Suh JH, Kim NS, Kim WH, Lim DS, Lee CW, Kim E. Negative feedback regulation of Aurora-A via phosphorylation of Fas- associated factor-1. J Biol Chem. 2008 Nov 21;283(47):32344-51. doi: 10.1074/jbc.M804199200. Epub 2008 Sep 12. PMID: 18790738.

94. Song MS, Song SJ, Kim SY, Oh HJ, Lim DS. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008 Jul 9;27(13):1863-74. doi: 10.1038/emboj.2008.115. Epub 2008 Jun 19. PMID: 18566590; PMCID: PMC2486425.

95. Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 8;2(5):497-507. doi: 10.1016/j.stem.2008.03.008. PMID: 18462699; PMCID: PMC2683414.

96. Lee JH, Kim TS, Yang TH, Koo BK, Oh SP, Lee KP, Oh HJ, Lee SH, Kong YY, Kim JM, Lim DS. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008 Apr 23;27(8):1231-42. doi: 10.1038/emboj.2008.63. Epub 2008 Mar 27. PMID: 18369314; PMCID: PMC2367404.

97. Hwang E, Ryu KS, Pääkkönen K, Güntert P, Cheong HK, Lim DS, Lee JO, Jeon YH, Cheong C. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9236-41. doi: 10.1073/pnas.0610716104. Epub 2007 May 21. PMID: 17517604; PMCID: PMC1890478.

98. Lee H, Lee DJ, Oh SP, Park HD, Nam HH, Kim JM, Lim DS. Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol Cell Biol. 2006 Jul;26(14):5373-81. doi: 10.1128/MCB.00043-06. PMID: 16809773; PMCID: PMC1592703.

99. Lee JH, Lim DS. Dual role of Nbs1 in the ataxia telangiectasia mutated- dependent DNA damage response. FEBS J. 2006 Apr;273(8):1630-6. doi: 10.1111/j.1742-4658.2006.05191.x. PMID: 16623700.

100. Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, Lee JH, Im CR, Lee JO, Yonehara S, Lim DS. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 2006 Mar 1;66(5):2562-9. doi: 10.1158/0008-5472.CAN-05-2951. PMID: 16510573.

101. Choi J, Park JH, Kwon OY, Kim S, Chung JH, Lim DS, Kim KS, Rhim H, Han YS. T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells. Brain Res. 2005 Aug 23;1054(1):22-9. doi: 10.1016/j.brainres.2005.05.010. PMID: 16054119.

102. Choi N, Son DS, Song I, Lee HS, Lim YS, Song MS, Lim DS, Lee J, Kim H, Kim J. RASSF1A is not appropriate as an early detection marker or a prognostic marker for non-small cell lung cancer. Int J Cancer. 2005 Jul 1;115(4):575-81. doi: 10.1002/ijc.20916. PMID: 15700308.

103. Song MS, Chang JS, Song SJ, Yang TH, Lee H, Lim DS. The centrosomal protein RAS association domain family protein 1A (RASSF1A)-binding protein 1 regulates mitotic progression by recruiting RASSF1A to spindle poles. J Biol Chem. 2005 Feb 4;280(5):3920-7. doi: 10.1074/jbc.M409115200. Epub 2004 Nov 16. PMID: 15546880.

104. Garg R, Callens S, Lim DS, Canman CE, Kastan MB, Xu B. Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Mol Cancer Res. 2004 Jun;2(6):362-9. PMID: 15235112.

105. Song MS, Lim DS. Control of APC-Cdc20 by the tumor suppressor RASSF1A. Cell Cycle. 2004 May;3(5):574-6. Epub 2004 May 25. PMID: 15107619.

106. Jang ER, Lee JH, Lim DS, Lee JS. Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns. J Cancer Res Clin Oncol. 2004 Apr;130(4):225-34. doi: 10.1007/s00432-003-0522-y. Epub 2004 Jan 23. PMID: 14745549.

107. Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol. 2004 Feb;6(2):129-37. doi: 10.1038/ncb1091. Epub 2004 Jan 25. PMID: 14743218.

108. Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res. 2003 Jul;1(9):674-81. PMID: 12861053.

109. Choi J, Chang JS, Song MS, Ahn BY, Park Y, Lim DS, Han YS. Association of hepatitis B virus polymerase with promyelocytic leukemia nuclear bodies mediated by the S100 family protein p11. Biochem Biophys Res Commun. 2003 Jun 13;305(4):1049-56. doi: 10.1016/s0006-291x(03)00881-7. PMID: 12767936.

110. Jeung JU, Cho SK, Shim KS, Ok SH, Lim DS, Shin JS. Construction of two pGEM-7Zf(+) phagemid T-tail vectors using AhdI-restriction endonuclease sites for direct cloning of PCR products. Plasmid. 2002 Sep;48(2):160-3. doi: 10.1016/s0147-619x(02)00122-1. PMID: 12383733.

111. Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol. 2002 Feb;22(4):1049-59. doi: 10.1128/MCB.22.4.1049-1059.2002. PMID: 11809797; PMCID: PMC134638.